Hybrid Methods in Iron-Sulfur Cluster Biogenesis
نویسندگان
چکیده
منابع مشابه
Hybrid Methods in Iron-Sulfur Cluster Biogenesis
Hybrid methods, which combine and integrate several biochemical and biophysical techniques, have rapidly caught up in the last twenty years to provide a way to obtain a fuller description of proteins and molecular complexes with sizes and complexity otherwise not easily affordable. Here, we review the use of a robust hybrid methodology based on a mixture of NMR, SAXS, site directed mutagenesis ...
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Iron-sulfur (FeS) clusters are among the most ancient and versatile protein cofactors. They are used by a large and diverse group of proteins, serving both structural and catalytic roles. They function in central metabolic processes such as electron transfer, redox chemistry, enzyme catalysis, and sensing environmental or intracellular conditions to regulate gene expression [1,2]. Ferrous iron ...
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Monothiol glutaredoxins play a crucial role in iron-sulfur (Fe/S) protein biogenesis. Essentially all of them can coordinate a [2Fe-2S] cluster and have been proposed to mediate the transfer of [2Fe-2S] clusters from scaffold proteins to target apo proteins, possibly by acting as cluster transfer proteins. The molecular basis of [2Fe-2S] cluster transfer from monothiol glutaredoxins to target p...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Biosciences
سال: 2017
ISSN: 2296-889X
DOI: 10.3389/fmolb.2017.00012